Hayden, Lystra P.
Hobbs, Brian D.
Busch, Robert
Cho, Michael H.
Liu, Ming
Lopes-Ramos, Camila M.
Lomas, David A.
Bakke, Per
Gulsvik, Amund
Silverman, Edwin K.
Crapo, James D.
Beaty, Terri H.
Laird, Nan M.
Lange, Christoph
DeMeo, Dawn L.
Funding for this research was provided by:
NIH/NHLBI (K23 HL136851, K08 HL136928, R01 HL113264, P01 HL114501, U01 HL089897, R01 HL089438)
NIH (T32HL007427)
NIH/NCI (R35 CA220523)
American Lung Association (LCD-821824)
CHEST Foundation (2016 grant in chronic obstructive pulmonary disease)
Article History
Received: 21 April 2022
Accepted: 18 January 2023
First Online: 1 February 2023
Declarations
:
: COPDGene obtained approval from the Institutional Review Board at each of the twenty-one clinical sites and all participants provided written informed consent for their medical data to be used prior to taking part in the study. ECLIPSE, GlaxoSmithKline study code SCO104960, was approved by the relevant ethics and review boards at the participating centers and all participants provided written informed consent. GenKOLS, GlaxoSmithKline study code RES11080, was approved by the Regional Committee for Medical Research Ethics (REK Vest), the Norwegian Data Inspectorate and the Norwegian Department of Health, and a written informed consent was obtained from all participants.COPDGene Clinical Center and IRB protocol numbers:Ann Arbor VA, Ann Arbor, MI (PCC 2008–110732).Baylor College of Medicine, Houston, TX (H-22209).Brigham and Women’s Hospital, Boston, MA (2007-P-000554/2; BWH).Columbia University, New York, NY (IRB-AAAC9324).Duke University Medical Center, Durham, NC (Pro00004464).Health Partners Research Foundation, Minneapolis, MN (07–127).Johns Hopkins University, Baltimore, MD (NA_00011524).Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, CA (12756–01).Michael E. DeBakey VAMC, Houston, TX (H-22202).Minneapolis VA, Minneapolis, MN (4128-A).Morehouse School of Medicine, Atlanta, GA (07–1029).National Jewish Health, Denver, CO (HS-1883a).Reliant Medical Group, Worcester, MA (1143).Temple University, Philadelphia, PA (11369).University of Alabama, Birmingham, AL (FO70712014).University of California, San Diego, CA (70876).University of Iowa, Iowa City, IA (200710717).University of Michigan, Ann Arbor, MI (HUM00014973).University of Minnesota, Minneapolis, MN (0801M24949).University of Pittsburgh, Pittsburgh, PA (PRO07120059).University of Texas Health Science Center at San Antonio, San Antonio, TX (HSC20070644H).ECLIPSE GSK Investigational Sites:Phoenix, Arizona, United States, 85006.Rancho Mirage, California, United States, 92270.Torrance, California, United States, 90502.Denver, Colorado, United States, 80206.Hartford, Connecticut, United States, 06105.New Haven, Connecticut, United States, 06519.Miami, Florida, United States, 33136.Boston, Massachusetts, United States, 02115.Boston, Massachusetts, United States, 02135.Baltimore, Maryland, United States, 21224.Rochester, Minnesota, United States, 55905.St. Charles, Missouri, United States, 63301.Omaha, Nebraska, United States, 68131.Omaha, Nebraska, United States, 68198.Lebanon, New Hampshire, United States, 03756.Pittsburgh, Pennsylvania, United States, 15213.Providence, Rhode Island, United States, 02903.Houston, Texas, United States, 77030.San Antonio, Texas, United States, 78229.Richmond, Virginia, United States, 23225.Pleven, Bulgaria, 5800.Sofia, Bulgaria, 1000.Vancouver, British Columbia, Canada, V5Z 1M9.Vancouver, British Columbia, Canada, V6Z 1Y6.Halifax, Nova Scotia, Canada, B3H 3A7.Hamilton, Ontario, Canada, L8N 3Z5.Kingston, Ontario, Canada, K7L 2V7.Montreal, Quebec, Canada, H2X 2P4.Sainte-Foy, Quebec, Canada, G1V 4G5.Praha 8, Czech Republic, 182 00.Hvidovre, Denmark, 2650.Horn, Netherlands, 6085 NM.Wellington, New Zealand, 6035.Bergen, Norway, N-5021.Golnik, Slovenia, 4204.Palma de Mallorca, Spain, 07014.Donetsk, Ukraine, 83003.Kiev, Ukraine, 03680.Kiev, Ukraine, 3680.Edinburgh, Midlothian, United Kingdom, EH16 4SA.Cambridge, United Kingdom, CB2 2XY.Liverpool, United Kingdom, L9 7AL.London, United Kingdom, NW3 2QG.Manchester, United Kingdom, M23 9LT.
: Not applicable.
: MHC has received Grant support from GSK and Bayer and speaking and consulting fees from AstraZeneca, Genentech and Illumina. DAL is supported by the NIHR UCLH Biomedical Research Centre and is an NIHR Senior Investigator, received grant support from GlaxoSmithKline, and received honoraria from Griffols and GlaxoSmithKline. PB has received payment or honoraria from AstraZeneca, Novartis, and Chiesi. In the past three years, EKS received grant support from GlaxoSmithKline and Bayer. DLD has received grant support from Bayer and honoraria from Novartis. Authors BDH, RB, ML, CMLR, AG, JDC, THB, NL, and CL have nothing additional to disclose.