Funding for this research was provided by:
Heart and Stroke Foundation of Canada
Received: 5 April 2019
Accepted: 28 June 2019
First Online: 5 July 2019
Ethics approval and consent to participate
: Human studies were approved by the University of Alberta Health Research Ethics Board, with the informed consent being obtained from all subjects. All animal protocols were approved by the University of Alberta Institutional Animal Care and Use Committee, which conform with the Guide for the Care and Use of Laboratory Animals published by the United States National Institutes of Health (eighth edition; revised 2011) and the guidelines of the Canadian Council on Animal Care.
: All authors have declared their consent for this publication.
: The authors declare that they have no competing interests.