Funding for this research was provided by:
Text and Data Mining valid from 2019-09-03
Received: 20 June 2019
Accepted: 22 August 2019
First Online: 3 September 2019
Ethics approval and consent to participate
: The trial was designed and overseen by a steering committee, and an independent data and safety monitoring committee performed regular safety surveillance. All patients provided written informed consent. Institutional review board approval was required at all participating institutions.
: Not applicable.
: MAN has been a member of advisory boards or consulted for AstraZeneca (moderate), Boehringer Ingelheim (moderate), Eli Lilly & Co. (significant), Fractyl (moderate), GlaxoSmithKline (moderate), Intarcia (moderate), Menarini/Berlin Chemie (moderate), Merck, Sharp & Dohme (significant), and NovoNordisk (significant). His institution has received grant support from AstraZeneca, Boehringer Ingelheim, Eli Lilly & Co., GlaxoSmithKline, Intarcia, Menarini/Berlin-Chemie, Merck, Sharp & Dohme, Novartis Pharma, and Novo Nordisk A/S. He has also served on the speakers’ bureau of AstraZeneca, Boehringer Ingelheim, Eli Lilly & Co., GlaxoSmithKline, Menarini/Berlin Chemie (all moderate), Merck, Sharp & Dohme, and Novo Nordisk A/S (both significant). DKM has provided clinical trial leadership for AstraZeneca, Sanofi Aventis, Janssen, Boehringer Ingelheim, Merck & Co, Pfizer, Lilly US, Novo Nordisk, Lexicon, Eisai, GlaxoSmithKline, and Esperion, and consultancy for AstraZeneca, Sanofi Aventis, Lilly US, Boehringer Ingelheim, Merck & Co, Novo Nordisk, Applied Therapeutics, Afimmune and Metavant. KSP has no disclosures. YL has received grants from Merck, Janssen Research & Development, AstraZeneca, GlaxoSmithKline, and Bayer HealthCare AG. TES reports personal fees from several companies (incl. Amgen, AstraZeneca, Merck, NovoNordisk, Pfizer, Orion, Bayer, Boehringer-Ingelheim) and owns a minor amount of stock in OrionPharma. AR has no disclosures. TD has no disclosures. EDP has received grants from Janssen, Merck, Sanofi, AstraZeneca, Genentech, and Amgen, and has consulting associations with Janssen, Bayer, Merck, and Sanofi. HDW reports research grants from GlaxoSmithKline, Sanofi-Aventis, Eli Lilly and Company, National Institute of Health, Merck Sharp & Dohme, George Institute, Omthera Pharmaceuticals, Pfizer New Zealand, Intarcia Therapeutics Inc., Elsai Inc., Daiichi-Sankyo, DalCor Pharmaceuticals; Advisory board/lecture fees from AstraZeneca, Acetelion, Sirte and he is a Steering Board member for Luitpold Pharmaceuticals Ltd and CSL Behring LLC. RS has no disclosures. RRH reports receiving grants from AstraZeneca during the conduct of the study and grants and personal fees from Bayer, Boehringer Ingelheim and Merck Sharp&Dohme Corp., a subsidiary of Merck & Co., Inc.; personal fees from Novartis, Amgen, and Servier; and financial support from Elcelyx, GlaxoSmithKline, Janssen, and Takeda outside the submitted work.