Funding for this research was provided by:
Text and Data Mining valid from 2019-10-22
Received: 15 August 2019
Accepted: 5 October 2019
First Online: 22 October 2019
Ethics approval and consent to participate
: The protocol was approved by local ethics committees and institutional review boards at each participating center. All subjects provided written informed consent.
: Not applicable.
: LEC, RCP, SB, DWB, SG, CDS, and JR are employees and/or shareholders of AstraZeneca. SG’s spouse is also an employee of AstraZeneca. HJLH serves on advisory panels for Boehringer Ingelheim GmbH and Merck & Co., Inc, and is a consultant for AbbVie Inc., AstraZeneca, Fresenius SE & Co. KGaA, Janssen Research & Development, and Mitsubishi Tanabe Pharma Corporation. RCP is a stockholder of Novartis Pharmaceuticals Corporation. DWB is a stockholder of Bristol-Myers Squibb Company. MT is a consultant for AstraZeneca. RJM has received research support and honoraria from AstraZeneca, GlaxoSmithKline plc., and Merck & Co., Inc. AFH is a consultant for Bayer AG & Boehringer Ingelheim Pharmaceuticals, Inc., and receives research support from AstraZeneca, GlaxoSmithKline plc., Janssen Pharmaceuticals, Inc., Merck & Co., Inc., and Novartis Pharmaceuticals Corporation. RRH has attended advisory boards at Elcelyx Therapeutics, Inc., Merck & Co., Inc., Novartis AG, Novo Nordisk A/S, Amylin, and Eli Lilly. RRH has given lectures supported by Bayer AG, Eli Lilly, Merck & Co., Inc, and Novo Nordisk A/S, and received research support and honoraria from AstraZeneca, Bayer AG, and Merck & Co., Inc. RRH is an Emeritus NIHR Senior Investigator. JBB’s contracted consulting fees are paid to the University of North Carolina by Adocia, AstraZeneca, Dance Biopharm, Eli Lilly, MannKind, NovaTarg, Novo Nordisk, Senseonics, vTv Therapeutics, and Zafgen; grant support from Novo Nordisk, Sanofi, and vTv Therapeutics. He is a consultant to Cirius Therapeutics Inc, CSL Behring, Neurimmune AG, and Whole Biome Inc. He holds stock options in Mellitus Health, PhaseBio, Stability Health, and Whole Biome Inc. He is supported by a grant from the National Institutes of Health (UL1TR002489).