Funding for this research was provided by:
the National Basic Research Program of China (2015CB554002)
the National Natural Science Foundation of China (81402277, 81472313, 81172055, 81472710, 81773196, 81702915, 81773101, 81672886, 81402375)
the Postdoctoral Science Foundation of China (2016M592511)
the Guangdong Provincial Natural Science Foundation of China (2014A030313283, 2016A030310395, 2016A030310394, 2016A030310392, 2017A030310117, 2017A030313463, 2017A030313583)
the Science and Technology Innovation Foundation of Guangdong Higher Education (CXZD1016)
Guangdong Medical Research Foundation (A2016218)
the Guangzhou Science & Technology Plan Project (201300000056)
Project of the National Natural Science Foundation of China supported by the NSFC-Guangdong Joint Fund (U1201226)
Received: 14 November 2018
Accepted: 2 May 2019
First Online: 10 May 2019
Ethics approval and consent to participate
: The Institutional Committee of Southern Medical University and Nanfang Hospital (Guangzhou, China) approved the collection of clinical materials for research purposes. All samples were collected and analyzed following prior written informed consent from each patient.
: The informed consent of patients was waived because the patients were all unconscious and the study did not involve additional procedures to the standardized clinical protocols, apart from the anonymous treatment of data.
: The authors declare that they have no competing interests.