Funding for this research was provided by:
National Natural Science Foundation of China (81802024, 81771696)
Department of Education of Guangdong Province (2016KZDXM033)
Natural Science Foundation of Guangdong Province (2018A030313217, 2020A1515010251)
Guangzhou science and technology project (202002030082)
Received: 4 October 2020
Revised: 9 January 2021
Accepted: 2 February 2021
First Online: 15 February 2021
Ethics approval and consent to participate
: All animal experiments were performed following the guidelines for the Administration of Affairs Concerning Experimental Animals (1988.11.1). All protocols for animal use were approved to be appropriate and humane by the institutional animal care and use committee of Guangzhou Medical University (2012-11). Every effort was made to minimize suffering.
: Not applicable.
: The authors declare that they have no competing interests.