Funding for this research was provided by:
bill and melinda gates foundation (MR/R006040/1)
Received: 16 June 2021
Accepted: 5 March 2022
First Online: 19 March 2022
: This methodology has received ethical approval from the Medical Research Coordinating Committee (MRCC) of the National Institute for Medical Research (NIMR) (NIMR/HQ/R.8a/Vol.IX/2743), Kilimanjaro Christian Medical University College (KCMUCO), and the London School of Hygiene and Tropical Medicine (LSHTM) (Ref: 16,524). For the community Phase III durability activity written informed consent will be obtained from an adult in the household (Additional file InternalRef removed). Written consent forms will also be obtained from volunteers (sleepers) who agree to participate in the hut study (Additional file InternalRef removed). Only adults of 18 years or older will be recruited, excluding pregnant women. Volunteers will be offered daily chemoprophylaxis and the risks of malaria explained (willingness to take will be an inclusion criterion). By sleeping under a mosquito net, they will obtain protection not dissimilar to exposure they would normally obtain against mosquitoes in their own home should they use a pyrethroid LLIN. Because an untreated net is used in one arm, all volunteers will be monitored each day for signs of fever. Confirmed falciparum parasitaemia will be treated with Coartem (artemether 20 mg/lumefantrine 120 mg) by a local physician. No side effects are expected from the LLIN except possibly some irritation to mucous membranes; these will be monitored and reported. Guinea pigs will be used in the partner Institutions in Tanzania to feed the colony mosquitoes. Restrained guinea pigs are also used in WHO tunnel test as bait. KCMUCo and NIMR laboratories in Tanzania have obtained approval from the Animal Welfare and Ethical Review Board of LSHTM (reference: 2019-14) for the use of animals for this study.
: Not applicable.
: The authors declare that they have no competing interests.