Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP19km0105001, JP19km0105002)
Received: 11 May 2020
Accepted: 27 July 2020
First Online: 3 August 2020
Ethics approval and consent to participate
: The protocol of this study was approved by the institutional review board of the Tohoku University Tohoku Medical Megabank Organization (2019–4–057) and KAGOME CO., LTD. (2018–R10). All participants provided informed consent.
: Not applicable.
: YY, TY, SS, and HS are employees of KAGOME CO., LTD., YY and TY are collaborative researchers of Tohoku University and KAGOME CO., LTD.