Funding for this research was provided by:
Scientific Research Program of the National Health and Family Planning Commission of China (201402014)
the National Natural Science Foundation of China grant (81570884, 81770961)
The ShuGuang Project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation (14sg18)
Received: 26 November 2019
Accepted: 3 July 2020
First Online: 15 July 2020
Ethics approval and consent to participate
: Written informed consent was obtained from all involved patients. This study was approved by the ethics committee of Shanghai Ninth People’s hospital. All the animal experiments were conducted strictly according to the Guide for the Care and Use of Laboratory Animals and approved by the Animal Care and Use Committee of the Shanghai Ninth People’s hospital.
: Written, informed consent was obtained for all involved patients. A form letter containing the carrier screening agreement for children younger than 18 years old was signed by their parents.
: The authors declare that they have no competing interests.