Funding for this research was provided by:
Received: 13 August 2020
Accepted: 19 October 2020
First Online: 12 November 2020
Ethics approval and consent to participate
: The study was registered on Clinicaltrials.gov (NCT03381287) and the study was conducted in accordance with the International Council for Harmonisation tripartite guideline on the ethical principles of Good Clinical Practice (ICHE6). The study was approved by Independent Ethics Committees (IECs) at each of the participating institutions and all subjects gave written informed consent to participate.
: All authors of the manuscript have read and agreed to its content and are accountable for all aspects of the accuracy and integrity of the manuscript in accordance with ICMJE criteria.This article is original, has not already been published in a journal, and is not currently under consideration by another journal.
: The following authors have potentially competing interests:AMD is a consultant to HighTide and Chief Medical Officer.GFW: Research grants and consultancy fees from Amgen, Sanofi, Regeneron, Arrowhead and Novartis.PL: Consultant to HighTide.LL, MY, RB: employees of HighTide Therapeutics.