Funding for this research was provided by:
National Natural Science Foundation of China (81773173, 81702453, 81702939)
Shanghai Science and Technology Development Foundation (17411951800, 19411952100, 17411965700)
Shanghai Jiao Tong University (YG2015QN42)
Natural Science Foundation of Shanghai (201440316)
School of Medicine, Shanghai Jiao Tong University (JZPI201701)
Shanghai Shen Kang Hospital Development Center (16CR2031B)
Shanghai “Rising Stars of Medical Talent” Youth Development Program (HU Health Personnel  No.72)
the Open Project of Key Laboratory of Systems Biomedicine (KLSB2017KF-03)
Received: 26 July 2020
Accepted: 5 November 2020
First Online: 18 November 2020
Ethics approval and consent to participate
: Authors state that they complied with the tenets of the Declaration of Helsinki or the NIH statement, and this study was approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, all patients involved in this study signed informed consent.
: Not applicable.
: The authors declare that they have no competing interests.