Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (HE 3544/2-2 and 2-3)
Received: 31 October 2018
Accepted: 15 February 2019
First Online: 2 March 2019
Ethics approval and consent to participate
: Planning and conduction of the experimental procedures as well as maintenance of the animals was carried out in accordance to the German Legislation for the Care and Use of Laboratory animals and the EU Directive 2010/63/EU for animal experiments. Experiments were approved by the State Office for Nature, Environment and Consumer Protection (LANUV, State of North Rhine-Westphalia, Germany) (87–51.04.2010.A061, 84–02.04.2011.A317).
: Not applicable.
: The authors declare that they have no competing interest regarding the publication of this paper or financial interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.