Funding for this research was provided by:
Natural Science Foundation of Anhui Province (1908085QH355)
National Natural Science Foundation of China (81901541)
National Key Technology R&D Program of China (2017YFC1002004)
National Key R&D Program of China (2019YFC1005106)
Received: 20 July 2020
Accepted: 12 February 2021
First Online: 20 February 2021
Ethics approval and consent to participate
: This study was approved and consented by the Ethics Committee of the First Affiliated Hospital of Anhui Medical University and the Ethics Committee of Xiamen Maternity and Child Care Hospital.
: All the individuals and their family members, as well as two controls signed written informed consents after having received complete information about the research.
: The authors declare that they have no competing interests.