Funding for this research was provided by:
Young Scientists Fund (81701513, 81501320)
Merck Company Foundation (MerckSerono_CREATE-2016116)
Specialized Research Fund for the Doctoral Program of Higher Education of China (20130071120095)
Major Research Plan (82071596)
Shanghai Municipal Education Commission-Gaofeng Clinical Medicine (20181803)
Received: 5 February 2021
Accepted: 19 June 2021
First Online: 2 July 2021
: All the subjects signed inform consent, and this study was approved by the Shanghai Jiaotong University Committee on the usage of human subjects in Medical research, and by the Institutional Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine (No. 2012–57).
: Not applicable.
: The authors declare that they have no competing interests.