Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (SFB/TR209 "Liver Cancer", SFB/TR209 "Liver Cancer")
Deutsche Krebshilfe (DKH 111524, DKH 70112699)
Received: 10 March 2020
Accepted: 31 July 2020
First Online: 23 October 2020
Ethics approval and consent to participate
: Human HCC cases were surgically resected at the University Hospital of Heidelberg and histologically classified by two experienced pathologists based on established criteria. Human tissue samples were provided by the Tissue Bank of the National Center of Tumor Diseases (NCT, Heidelberg, Germany) in accordance with the regulations of the Tissue Bank and the approval of the Ethics Committee of Heidelberg University (application no. 206/05). Human HCC cases were surgically resected at the University Hospital of Mainz and histologically classified (<i>n</i> = 19). The study was approved by the institutional ethics committee of the Landesärztekammer Rheinland Pfalz (837.146.17; 10980).Animal work was authorized by the German Regional Council of Baden-Württemberg (Regierungspräsidium Karlsruhe) according to the EU directive 2010/63EU. All experiments were performed in accordance with the institutional regulations of the IBF (Interfakultäre Biomedizinische Forschungseinrichtung, University of Heidelberg) under pathogen-free (SPF) conditions. The mouse colony was housed under a 12 h light/dark cycle with free access to water and food. Exclusion and termination criteria were defined in the ATBW criteria.
: Not applicable.
: The authors declare that they have no competing interests.