Received: 31 March 2020
Accepted: 30 November 2020
First Online: 20 January 2021
Ethics approval and consent to participate
: The study protocol was approved by the Ethics Committee of the First Hospital of Qinhuangdao and performed in strict accordance with the <i>Declaration of Helsinki</i>. All participants provided signed written informed consent documentation prior to enrollment. Animal experiments were approved by the Animal Ethics Committee and strictly performed according to the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health. Extensive efforts were made to ensure minimal numbers and suffering of the included animals.
: Not applicable.
: The authors declare that they have no competing interests.