Clinical trials referenced in this document:
Funding for this research was provided by:
Research for Patient Benefit Programme (PB-PG-0215-36039PB)
Received: 12 August 2021
Accepted: 23 October 2021
First Online: 6 November 2021
: Ethical approval was obtained for the study from The National Research Ethics Service Committee Northwest Coast-Preston (16/NW/0273). Separate ethical approval was obtained for the mechanistic open label study NRES-Liverpool East Research Ethics Committee (17/NW/0234).
: Not applicable.
: SJ receives Ph.D. funding from The Pain Research Institute Liverpool. WM and FH have received funding from German Research Foundation (DFG) and German Ministry of Education and Research (BMBF). AG is supported by the Pain Relief Foundation, Liverpool. BF has been paid honoraria and consultancy fees by Gruenenthal and Astellas and received consultancy fees from BCI Pharma. AM, EH, DH, TJN, PB, MLS and AM report no conflict of interests.