Capasso, Mario
Brignole, Chiara
Lasorsa, Vito A.
Bensa, Veronica
Cantalupo, Sueva
Sebastiani, Enrico
Quattrone, Alessandro
Ciampi, Eleonora
Avitabile, Marianna
Sementa, Angela R.
Mazzocco, Katia
Cafferata, Barbara
Gaggero, Gabriele
Vellone, Valerio G.
Cilli, Michele
Calarco, Enzo
Giusto, Elena
Perri, Patrizia
Aveic, Sanja
Fruci, Doriana
Tondo, Annalisa
Luksch, Roberto
Mura, Rossella
Rabusin, Marco
De Leonardis, Francesco
Cellini, Monica
Coccia, Paola
Iolascon, Achille
Corrias, Maria V.
Conte, Massimo
Garaventa, Alberto
Amoroso, Loredana
Ponzoni, Mirco http://orcid.org/0000-0002-6164-4286
Pastorino, Fabio
Funding for this research was provided by:
Ministero della Salute (Ricerca Finalizzata 5 per mille, Ricerca Corrente)
Associazione Italiana per la Lotta al Neuroblastoma
Associazione Oncologia Pediatrica e Neuroblastoma ONLUS
Associazione Italiana per la Ricerca sul Cancro (24397, 25796)
Article History
Received: 25 October 2023
Accepted: 3 February 2024
First Online: 13 February 2024
Declarations
:
: Samples derived from Schwannian-stroma poor, poorly differentiated, NB primary tumors at relapse and BM<i>-</i>infiltrating NB cells from patients at either onset or relapse were provided by BIT (Integrated Tumor Bio-Bank of Gaslini Institute, Tissue Section), Istituto G. Gaslini, Genoa, Italy. All procedures were performed in accordance with relevant guidelines and regulations and approved by the CER (Regional Committee), first under the protocol ANTECER_Neuroblastoma: 15/12/2016, amendment 065_16/09/2019, and subsequently under the protocol EudraCT: 2022-000558-27. Informed consent was obtained from each patient in accordance with the Declaration of Helsinki. Male NOD/SCID/IL2Rgamma<sup>null</sup> (NSG) mice (Charles River Laboratories, Milan, Italy) were housed under pathogen-free conditions. In accordance with the 3Rs policy, experiments were reviewed and approved by the licensing and ethical committee of Ospedale Policlinico San Martino and by the Italian Ministry of Health (n. 661/2016-PR and 883/2020-PR).
: Supporting data and materials are available.
: All authors approved the final version of the manuscript. MP had responsibility for the decision to submit for publication.
: The authors declare that they have no competing interests.