Funding for this research was provided by:
National Institutes of Health (K23HL118529, 1R21HL127650, 1R01HL129185)
American Heart Association (15EIA22710040)
Received: 27 December 2017
Accepted: 2 March 2018
First Online: 22 March 2018
Ethics approval and consent to participate
: This study was approved by the Institutional Review Board at Beth Israel Deaconess Medical Center, Harvard University. All subjects provided informed consent for research participation. For the animal experiments, the protocol was approved by the local Institutional Animal Care and Use Committee (IACUC) at Beth Israel Deaconess Medical Center.
: Not applicable
: RN and TAB hold patent on the use of nulling signals from two or more tissues to better delineate an interested tissues (US Patent 2016/126,659 A1). The authors declare that they have no other competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Dr. Peter Kellman served as a Guest Editor for this manuscript.