Funding for this research was provided by:
National Institutes of Health (HL137100, GM103545, HL127564, MH096100)
National Science Foundation (DBI-1147260)
Received: 9 July 2019
Accepted: 5 March 2020
First Online: 2 April 2020
: All animal studies were approved by the Institutional Animal Care and Use Committee at UCSD and followed the NIH Guide for the Care and Use of Laboratory Animals.
: Not applicable.
: AM and JO are co-founders of and have an equity interest in Insilicomed, and AM has an equity interest in Vektor Medical. AM and JO serve on the scientific advisory board of Insilicomed, and AM as scientific advisor to both companies. Some of their research grants, including those acknowledged here, have been identified for conflict of interest management based on the overall scope of the project and its potential benefit to these companies. The authors are required to disclose this relationship in publications acknowledging the grant support, however the research subject and findings reported here did not involve the companies in any way and have no specific relationship with the business activities or scientific interests of either company. The terms of this arrangement have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies.