Received: 23 May 2020
Accepted: 24 February 2021
First Online: 22 March 2021
: The AID-registry has been approved by the ethics committees and the data protection responsibles at the University of Duisburg-Essen and Muenster, as well as the Medical Association Nordrhein in Duesseldorf. Parents, children between 9 and 13 years of age and young patients aged ≥14 years provide informed consent.
: Each author listed on the manuscript has approved the submission of the manuscript.
: EL received speaker honoraria from Novartis and SOBI. TK received speaker honoraria from Novartis, SOBI and Roche as well as research report from Novartis. HW received speaker honoraria from Novartis, Shire/Takeda and CSL-Behring. GH received support for scientific studies from Abbvie, Chugei, MSD, Novartis, Pfizer, Roche and honoraria from Abbvie, Chugai, GSK, Pfizer and Novartis. UN received speaker honoraria from Roche and support for 2 meetings by SOBI. PTO received research funding from Novartis. KT received support from SOBI, grants from Pfizer and Novartis Medical Foundation. CH received honoraria from Novartis. RB, CR, TL, BH, NF, MB, BR, RMK, JK, JPH, EL, GLH declare that they have no conflict of interest. DW received speaker honoraria from Abbvie and Pfizer as well as research support from Novartis and Roche. DF received speaker honoraria from Novartis, SOBI and Roche as well as research report from Novartis, SOBI and Pfizer.EWR received honoraria for advisory boards and travel support from Novartis, SOBI and Roche. FWH received speaker honoraria from Novartis, SOBI and Roche. TN received authorship fees from ExternalRef removed (Wellesley, Massachusetss, USA) and reimbursement of travel expenses during consultancy work from European Medicines Agency (EMA), steering committees of the PENTA (Pediatric European Network For Treatment of AIDS) (Padua, Italy), the Juvenile Inflammatory Cohort (JIR) (Lausanne, Switzerland), and, until 2017, the FIND-ID Initiative (supported by the Plasma Protein Therapeutic Association (PPTA) (Brussels, Belgium).