Funding for this research was provided by:
Conselho Nacional de Desenvolvimento Científico e Tecnológico (NA)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)
Fundação de Amparo à Pesquisa do Estado de São Paulo (NA)
Fundação Araucária (NA)
Financiadora de Estudos e Projetos (NA)
Received: 26 September 2018
Accepted: 30 April 2019
First Online: 28 May 2019
Ethics approval and consent to participate
: The animal protocol was approved by the Institutional Ethics Committee on Animal Use (CEUA) of Universidade Estadual de Londrina (UEL) under the process number 1067.2015.64. All animal experiments were carried out in accordance with the Brazilian Council on Animal Experimentation (CONCEA) and the Directive 2010/63/EU for animal experiments and in accordance with the International Association for Study of Pain (IASP) guidelines. The maintenance and handling of the mice were consistent with the guidelines of the National Institute of Health, and adequate measures were taken to minimize animal discomfort.
: All authors agree with the manuscript publication.
: The authors declare that they have no competing interests.
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