Funding for this research was provided by:
ZonMw (Veni 916.12.113)
H2020 Marie Skłodowska-Curie Actions (grant 642870, ETN Immunoshape)
Stichting MS Research (14-878MS, 14-865MS, MS09-924)
Received: 7 November 2018
Accepted: 13 June 2019
First Online: 27 June 2019
Ethics approval and consent to participate
: Brain tissue samples were obtained from The Netherlands Brain Bank (coordinator Dr. Huitinga, Amsterdam, The Netherlands). The Netherlands Brain Bank received permission to perform autopsies for the use of tissue and for the access to medical records for research purposes from the Ethical Committee of the VU University Medical Center, Amsterdam, The Netherlands. All patients and controls, or their next of kin, had given informed consent for autopsy and the use of brain tissue for research purposes. The animal experimental protocol was validated and approved by the local ethical committee on animal experimentation of the VU University Medical Center.
: Not applicable
: The authors declare that they have no competing interests.