Funding for this research was provided by:
Grants-in-Aid for Scientific Research (18K06687)
Matching Fund Subsidy for Private University from the Ministry of Education, Culture, Sports, Science and Technology of Japan (S1511001L, S1511001L, S1511001L)
Received: 7 June 2019
Accepted: 10 September 2019
First Online: 31 October 2019
Ethics approval and consent to participate
: All experiments were performed following the approval of the Ethics Committee for Animal Experiments at Tohoku Medical and Pharmaceutical University (approval numbers: 16023 cn, 17015 cn, and 18031 cn) and according to the tenets of the National Institutes of Health Guide for the Care and Use of Laboratory Animals. All efforts were made to minimize the suffering of the animals and reduce the number of animals used.
: Not applicable.
: Hiroyuki Iwasa is an employee of Nihon Berm Co., Ltd. All other authors declare that they have no competing interests.