Funding for this research was provided by:
National Institute on Aging (AG12411)
Windgate Foundation (N/A)
Ottenheimer Brothers Foundation (N/A)
Philip R Jonsson Foundation (N/A)
STOP Alzheimer's (N/A)
Inglewood Foundation (N/A)
Received: 15 August 2019
Accepted: 2 December 2019
First Online: 27 December 2019
Ethics approval and consent to participate
: Human tissues used for this study were collected at autopsy for reasons other than for this study and were judged as exempt from Federal regulations on human subjects via exemption 4, with Human Subject Assurance Number 00001119 by the University of Arkansas for Medical Sciences Institutional Review Board. Animal studies were carried out in strict accordance with the recommendations of US National Institutes of Health Guide for the Care and Use of Laboratory Animals. The protocol was approved by the Institutional Animal Care and Use Committee (IACUC approval number: a3063-01). All efforts were made to minimize pain and suffering.
: Not applicable
: The authors declare that they have no competing interests.