Funding for this research was provided by:
National Institute of Neurological Disorders and Stroke (R35 NS097303)
National Institute of Allergy and Infectious Diseases (K22 AI125466)
Received: 27 February 2020
Accepted: 29 May 2020
First Online: 12 June 2020
Ethics approval and consent to participate
: Unidentified postmortem brain specimens for microarray analysis were obtained from the UK Multiple Sclerosis Tissue Bank and the Human Brain and Spinal Fluid Resource Center at UCLA after obtaining approval of the Institutional Review Board at both institutions. All tissues used for IHC analysis were collected as part of the tissue procurement program approved by the Cleveland Clinic Institutional Review Board. Animals were housed in a specific pathogen-free barrier facility at the Cleveland Clinic Lerner Research Institute (Cleveland, OH, USA). All experiments were performed in compliance with and under the approval of the Cleveland Clinic Institutional Animal Care and Use Committee.
: Not applicable
: The authors declare that they have no competing interests.