Funding for this research was provided by:
National Research Foundation of Korea (MRC, 2017R1A5A2015541)
Received: 14 July 2020
Accepted: 2 November 2020
First Online: 22 November 2020
Ethics approval and consent to participate
: The experimental protocols were carried out according to the guidelines for animal experiments of the Faculty of Disease Animal Model Research Center, Korea Research Institute of Bioscience and Biotechnology (Daejeon, Korea), as well as the Institutional Animal Care and Use Committee (IACUC) of the Laboratory Animal Research Center at Chungbuk National University, Korea (ethics approval No. CBNUA-1329-19-01). All efforts were made to minimize animal suffering and to reduce the number of animals used. All mice were housed in cages automatically maintained at 21–25 °C and relative humidity of 45–65% with a controlled 12-h light-dark cycle illuminating from 06:00 a.m. to 06:00 p.m. Food and water were available ad libitum. They were fed a pellet diet consisting of crude protein 20.5%, crude fat 3.5%, crude fiber 8.0%, crude ash 8.0%, calcium 0.5%, and phosphorus 0.5% per 100 g of the diet (obtained from Daehan Biolink, Chungcheongbuk-do, Korea).
: Not applicable.
: The authors declare that they have no competing interests.