Funding for this research was provided by:
National Cancer Institute (R01CA197488, P50 CA108961)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099528)
National Institute of Biomedical Imaging and Bioengineering (T32EB019944)
Mayo Clinic Brain Tumor Patient-Derived Xenograft National Resource (R24 NS092940)
Received: 5 August 2020
Accepted: 5 November 2020
First Online: 18 November 2020
Ethics approval and consent to participate
: Patient-derived xenograft models. Accrual of patient tumor samples to originally develop these models was performed with approval by the Mayo Clinic Institutional Review Board. The xenograft models being used in this project are derived from patients who are now deceased and therefore do not constitute human subjects research as per NIH guidelines.Primary mouse microglia. All animal care protocols were in accordance with NIH Guidelines for Care and Use of Laboratory Animals and were approved by the University of Illinois Laboratory Animal Care and Use Committee and by the Mayo Clinic Institutional Animal Care and Use Committee.
: All authors of the manuscript have read and agreed to its content and are accountable for all aspects of the accuracy and integrity of the manuscript.
: The authors declare that they have no competing interests.