Funding for this research was provided by:
Jane ja Aatos Erkon Säätiö
State Research Funding of Turku University Hospital (ERVA#13303)
Sigrid Juséliuksen Säätiö
Alfred Kordelinin Säätiö
Drug Research Doctoral Programme of the University of Turku Graduate School
Received: 12 August 2020
Accepted: 5 January 2021
First Online: 20 January 2021
Ethics approval and consent to participate
: All animal experiments were approved by the National Animal Experiment Board of Finland and the Regional State Administrative Agency for Southern Finland (license number: ESAVI/2979/2018) and conducted in accordance with the relevant European Union directive. The study of archival human tissues was approved by the Auria Biobank Scientific Steering Committee (decision AB19-2623). According to the Finnish Biobank Act (688/2012), separate informed consent from individual patients is not needed.
: Not applicable.
: Michael Pugh and Yingjuan June Lu are full-time employees of Novartis. All other authors declare no potential conflicts of interest.