Gudenschwager Basso, Erwin K.
Ju, Jing
Soliman, Eman
de Jager, Caroline
Wei, Xiaoran
Pridham, Kevin J.
Olsen, Michelle L.
Theus, Michelle H.
Funding for this research was provided by:
National Institute of Neurological Disorders and Stroke (NS096281)
Article History
Received: 25 August 2023
Accepted: 26 January 2024
First Online: 3 February 2024
Declarations
:
: Animals and under the approval of the Virginia Tech Institutional Animal Care and Use Committee (IACUC; #18-116 and #21-044) and the Virginia-Maryland College of Veterinary Medicine.
: Monocytes regulate tissue damage and repair in the brain. The effects of sterile brain injury on their phenotypic identity and recruitment, under emergency conditions were studied at the single-cell level. Our work has uncovered a novel immunoregulatory state that may be sufficient to provide neuroprotection.
: The authors have declared that no conflict of interest exists. The authors declare no competing financial interests.