Funding for this research was provided by:
National Institute on Aging (R21AG062932)
Received: 4 November 2020
Accepted: 2 February 2021
First Online: 13 February 2021
Ethics approval and consent to participate
: Two types of human specimens were used in this study: (a) colonic tissue samples obtained from discarded surgical tissue and (b) archived frozen PBMC.<i>Colonic tissue samples</i>: Patients gave informed consent to allow unrestricted use of tissue specimens in research and all samples were de-identified to laboratory staff with only age, sex, the reason for surgery and relevant treatment status information available. The use of these samples for research purposes was reviewed by the Colorado Multiple Institutional Review Board (COMIRB) at the University of Colorado Anschutz Medical Campus and met criteria defined by their policies formed in accordance with regulations outlined by the FDA and OHRP, to be deemed “Not Human Research”. (Protocols 07–0493 and 17–1746).<i>PBMC samples</i>: All donors voluntarily gave written, informed consent. This study was approved by the COMIRB at the Anschutz Medical Campus. (Protocols 98–496 and 11–1644).
: Not applicable.
: The authors declare that they have no competing interests.