Funding for this research was provided by:
National Natural Science Foundation of China (No. 81870319, 81600327, No. 81700368)
National Key R&D Program of China (2016YFC1300100)
the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaoton University (No.XJTU1AF-CRF-2019-004)
the Major Chronic Non-communicable Disease Prevention and Control Research Key Project of the Ministry of Science and Technology of the People’s Republic of China (Grant 2017YFC1307604)
the Key Research Project of Shaanxi Province (Grant 2017ZDXM-SF-107)
Received: 3 January 2020
Accepted: 25 June 2020
First Online: 2 July 2020
Ethics approval and consent to participate
: This study was approved by the First Affiliated Hospital of Xi’an Jiao Tong University (trial registration number: NCT02734472; date of registration: 12/04/2016). The protocols were in accordance with the principles of the Helsinki Declaration. We obtained written informed consent from the children and their guardians in childhood and from the subjects in adulthood.
: Not applicable.
: All the authors declare that there were no conflicts of interest in this study.