Funding for this research was provided by:
the cultivation fund of national natural science foundation of china in shandong provincial qianfoshan hospital (QYPY2020NSFC1004)
the key technology research and development program of shandong (2017G006024)
national natural science foundation of china (81400843)
natural science foundation of shandong province (ZR2014HP033)
Received: 9 July 2021
Accepted: 30 November 2021
First Online: 12 January 2022
: This study was approved by the ethics committee of the Ethics Committee of Shandong University (No:  S048).
: Not applicable.
: The authors declare they have no competing interests.