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Article History

Received: 30 August 2023

Accepted: 23 April 2024

First Online: 9 May 2024

Declarations

:

: Informed consent was obtained from each participant and the study was approved by the Vanderbilt University Medical Center Institutional Review Board.

: Manus J. Donahue receives research related support from the National Institutes of Health (NINDS, NCI, NIA, NCCIH, NINR, and NHLBI), Philips Healthcare and is a paid consultant for Graphite Bio, Pfizer Inc, Global Blood Therapeutics, and LymphaTouch. He is a paid advisory board member for Novartis and bluebird bio and receives research funding from the National Institutes of Health and Pfizer Inc. Manus J. Donahue is also the CEO of Biosight Inc which operates as a clinical research organization and provides healthcare technology vendor services. Ciaran Considine’s financial disclosures include those associated with his private consulting practice, NeuropsyConsulting LLC, i.e., Forensic Consulting with Park Dietz & Associates, clinical-research advisory panel member with MDisrupt, external advisory board for HD Genetics. He also receives academic-research grant support from the NIH, NIA, and DoD, and acts as PI on an investigator-initiated clinical study funded by Acadia. Daniel O. Claassen has received research support from the NIH/NINDS/NIA/NICHD/NCCIH, Department of Defense, Griffin Family Foundation, and Huntington Disease Society of America; he has received pharmaceutical grant support from AbbVie, Alterity, Acadia, Biogen, BMS, Cerecour, Eli Lilly, Genentech-Roche, Lundbeck, Jazz Pharmaceuticals, Neurocrine, Teva Neuroscience, Wave Life Sciences, UniQure, and Vaccinex. He has received personal fees for consulting from Acadia, Alterity, Adamas, Anexon, Ceruvel, Lundbeck, Neurocrine, Spark, Uniqure, and Teva Neuroscience.

: Available upon request.

: No authors declare any relevant conflicts or disclosures regarding the work presented in this manuscript. Manus J. Donahue receives research related support from the National Institutes of Health (NINDS, NCI, NIA, NCCIH, NINR, and NHLBI), Philips Healthcare and is a paid consultant for Graphite Bio, Pfizer Inc, Global Blood Therapeutics, and LymphaTouch. He is a paid advisory board member for Novartis and bluebird bio and receives research funding from the National Institutes of Health and Pfizer Inc. Manus J. Donahue is also the CEO of Biosight Inc which operates as a clinical research organization and provides healthcare technology vendor services. Ciaran Considine?s financial disclosures include those associated with his private consulting practice, NeuropsyConsulting LLC, i.e., Forensic Consulting with Park Dietz & Associates, clinical-research advisory panel member with MDisrupt, external advisory board for HD Genetics. He also receives academic-research grant support from the NIH, NIA, and DoD, and acts as PI on an investigator-initiated clinical study funded by Acadia. Daniel O. Claassen has received research support from the NIH/NINDS/NIA/NICHD/NCCIH, Department of Defense, Griffin Family Foundation, and Huntington Disease Society of America; he has received pharmaceutical grant support from AbbVie, Alterity, Acadia, Biogen, BMS, Cerecour, Eli Lilly, Genentech-Roche, Lundbeck, Jazz Pharmaceuticals, Neurocrine, Teva Neuroscience, Wave Life Sciences, UniQure, and Vaccinex. He has received personal fees for consulting from Acadia, Alterity, Adamas, Anexon, Ceruvel, Lundbeck, Neurocrine, Spark, Uniqure, and Teva Neuroscience.