Funding for this research was provided by:
Received: 24 August 2020
Accepted: 6 November 2020
First Online: 12 November 2020
Ethics approval and consent to participate
: The underlying trials (NCT01280032 and NCT02773966) were approved by the institutional review board, Ethikkommission II, Mannheim Medical Faculty, Heidelberg University. All patients gave their written consent before participation.
: Not applicable.
: LW, GW, UO, FW and AMR have no competing interests to disclose. FB and FS report grants and personal fees from Carl Zeiss Meditec AG, during the conduct of the study; FG reports grants, personal fees, and patents from or related to Carl Zeiss Meditec AG, grants from Elekta AB; grants and personal fees from NOXXON Pharma AG, personal fees from Bristol-Myers Squibb, personal fees from Roche Pharma AG, personal fees from MSD Sharp and Dohme GmbH, personal fees from AstraZeneca GmbH, non-financial support from Oncare GmbH, outside the submitted work.