Coccolini, Federico
,
Moore, Ernest E.
Kluger, Yoram
Biffl, Walter
Leppaniemi, Ari
Matsumura, Yosuke
Kim, Fernando
Peitzman, Andrew B.
Fraga, Gustavo P.
Sartelli, Massimo
Ansaloni, Luca
Augustin, Goran
Kirkpatrick, Andrew
Abu-Zidan, Fikri
Wani, Imitiaz
Weber, Dieter
Pikoulis, Emmanouil
Larrea, Martha
Arvieux, Catherine
Manchev, Vassil
Reva, Viktor
Coimbra, Raul
Khokha, Vladimir
Mefire, Alain Chichom
Ordonez, Carlos
Chiarugi, Massimo
Machado, Fernando
Sakakushev, Boris
Matsumoto, Junichi
Maier, Ron
di Carlo, Isidoro
Catena, Fausto
Article History
Received: 10 September 2019
Accepted: 23 October 2019
First Online: 2 December 2019
Ethics approval and consent to participate
: Not applicable.
: Not applicable.
: The authors declare that they have no competing interests.(<b>*:</b> NOM should only be attempted in centers capable of a precise diagnosis of the severity of kidney injuries and capable of intensive management (close clinical observation and hemodynamic monitoring in a high dependency/intensive care environment, including serial clinical examination and laboratory assay, with immediate access to diagnostics, interventional radiology and surgery and immediately available access to blood and blood products or alternatively in presence of a rapid centralization system in those patients amenable to be transferred; <b>@:</b><b><i>Hemodynamic instability</i></b><b>in adults</b> is considered the condition in which patient has an admission systolic blood pressure < 90 mmHg with evidence of skin vasoconstriction (cool, clammy, decreased capillary refill), altered level of consciousness and/or shortness of breath, or > 90 mmHg but requiring bolus infusions/transfusions and/or vasopressor drugs and/or admission base excess (BE) >-5 mmol/l and/or shock index > 1 and/or transfusion requirement of at least 4-6 Units of packed red blood cells within the first 24 h; moreover <i>transient responder patients</i> (those showing an initial response to adequate fluid resuscitation, and then signs of ongoing loss and perfusion deficits) and more in general those responding to therapy but not amenable of sufficient stabilization to be undergone to interventional radiology treatments. <b>In pediatric patients:</b><b><i>Hemodynamic stability</i></b> is considered systolic blood pressure of 90 mmHg plus twice the child’s age in years (the lower limit is inferior to 70 mmHg plus twice the child’s age in years, or inferior to 50 mmHg in some studies), Stabilized or acceptable hemodynamic status is considered in children with a positive response to fluids resuscitation: 3 boluses of 20 mL/kg of crystalloid replacement should be administered before blood replacement; positive response can be indicated by the heart rate reduction, the sensorium clearing, the return of peripheral pulses and normal skin color, an increase in blood pressure and urinary output, and an increase in warmth of extremity. Clinical judgment is fundamental in evaluating children.