Funding for this research was provided by:
Ministry of Science and Technology, Taiwan (MOST-105-2628-B-195-001-MY3, MOST-105-2314-B-195-013, MOST-102-2314-B-195-017-MY3, MOST-104-2314-B-195-019, MOST-102-2314-B-195-006)
Mackay Memorial Hospital (MMH-103-092, MMH-101-111, MMH-I-S-600)
Shire, Lexington, MA, USA
Shire, Zug, Switzerland
Text and Data Mining valid from 2018-06-04
Received: 13 October 2017
Accepted: 18 May 2018
First Online: 4 June 2018
Ethics approval and consent to participate
: Independent Review Board/Ethics Committee approval was obtained for all participating centres. HOS is conducted in accordance with Good Pharmacoepidemiological Practices (GPP), Good Research for Comparative Effectiveness principles and the relevant principles of the International Conference on Harmonisation (ICH) Good Clinical Practice (GCP) guidelines (ICH E6). Each patient, their parents or a legal representative provided signed and dated written informed consent for participation in HOS. All patient information is managed in accordance with national data protection standards.
: Each patient, their parents, or a legal representative provided informed consent for publication of data.
: Professor Shuan-Pei Lin has received grant support and honoraria for speaking engagements from Shire, BioMarin and Sanofi-Genzyme.Dr. Ju-Li Lin received grants from Shire during the conduct of the study.Dr. Hsiang-Yu Lin has received grant support and honoraria for speaking engagements from Shire, BioMarin and Sanofi-Genzyme.All other authors declare that they have no conflict of interest.
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