Funding for this research was provided by:
Received: 8 May 2018
Accepted: 8 October 2018
First Online: 9 November 2018
Ethics approval and consent to participate
: The CHESS study received ethics approval from the University of Chester Ethics Committee. All patients or their legal representatives provided signed informed consent to participate in this study.
: Not applicable.
: AO and ML are employees and shareholders of Shire. SW was an employee of HCD at the time the study was completed. TLK was an employee of Shire at the time the study was completed.
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