Funding for this research was provided by:
Ministère des Affaires Sociales et de la Santé (PHRC 2012-A00466-37)
Union Européenne (This work was supported by grants from EU-funded (ERDF) project INTERREG V “RARENET”.)
Received: 1 March 2018
Accepted: 28 December 2018
First Online: 11 January 2019
Ethics approval and consent to participate
: Ambulatory patients involved in PHRC T21 “Trisomy 21 in Adulthood”: (Dr Alembik Yves): All subjects were recruited under a protocol approved by ethical board CPP-Est IV N°12/47 (research ethical board of Strasbourg University Hospital) including a written informed consent.Retrospective hospitalized patients: An approval statement from the local ethical committee has been obtained (ethical committee of the Faculties of Medicine and Dentistry of Strasbourg N°2018–8).
: Not applicable.
: The authors declare that they have no competing interests.
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