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Article History

Received: 27 November 2018

Accepted: 8 April 2019

First Online: 29 April 2019

Ethics approval and consent to participate

: This study was approved by Ethical and Independent Review Services, and informed consent was obtained from all individual participants included in the study. All research performed was in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Written informed consent for publication of the study results was obtained from the parents of the patients. A copy of the consent form is available for review by the Editor of this journal.

: Magdalena Harrington was an employee of Shire (a Takeda company) when this research was performed, and is now an employee of Pfizer.Diane Whalley, James Twiss, Rebecca Rushton and Susan Martin are employees of RTI Health Solutions.Lynn Huynh and Hongbo Yang are employees of Analysis Group, Inc.

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