Funding for this research was provided by:
Received: 22 March 2019
Accepted: 29 April 2019
First Online: 7 June 2019
Ethics approval and consent to participate
: The protocols for all four studies were approved by the institutional review boards or independent ethics committees of participating institutions (See list in Additional file InternalRef removed).
: Not applicable.
: The authors are currently employees of Sanofi Genzyme.
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