Funding for this research was provided by:
National Heart, Lung, and Blood Institute (NIH R01 HL131784, R01HL136833)
Received: 5 March 2019
Accepted: 25 June 2019
First Online: 4 July 2019
Ethics approval and consent to participate
: All patients provided written informed consent to protocols 95-HG-0193 (ExternalRef removed NCT00001456) and 04-HG-0211 (ExternalRef removed NCT00084305). All study protocols were approved by the Institutional Review Boards at Thomas Jefferson University and the National Human Genome Research Institute prior to the initiation of any studie.
: All the co-authors have read the manuscript and approved its submission to “Orphanet Journal of Rare Disease”.
: The authors declare that they have no competing interests.