Pesl, Martin
Jelinkova, Sarka
Caluori, Guido
Holicka, Maria
Krejci, Jan
Nemec, Petr
Kohutova, Aneta
Zampachova, Vita
Dvorak, Petr
Rotrekl, Vladimir
Funding for this research was provided by:
Lékařská fakulta, Masarykova univerzita (MUNI/A/1087/2018, MUNI/A/1493/2018, ROZV/23/LF8/2019, ROZV/23/LF9/2019)
Ministerstvo Školství, Mládeže a Tělovýchovy (7AMB13FR011, CZ.02.1.01/0.0/0.0/16_019/0000868, LQ1605, LQ1601)
Article History
Received: 23 July 2019
Accepted: 19 November 2019
First Online: 5 March 2020
Ethics approval and consent to participate
: This study was carried out in accordance with the recommendations of the Masaryk University Ethics Committee and St. Ann’s University Hospital Ethics Committee, issuing approval nr. 51 V/2015 - approved consent for heart tissue sampling and analysis, and genetic information analysis (DNA and circulating free DNA), protocol was approved on 12th August 2015. The “healthy donor” (HD) control samples were obtained from donors diagnosed with brain death. The hearts were brought to the transplantation center for transplantation and were provided for scientific analysis after the anonymization of donor data. Thus, individual information, such as names of donors, was not available to investigators. Samples from deceased donors were not further addressed by the ethics committee since the transplantation system is opt-out according to the law 285/2002 Sb. in the Czech Republic. At the same time, due to anonymization, family members were not reachable.
: The study subject gave written informed consent regarding explanted organ sampling and publication of results.
: The authors declare that they have no competing interests.