Naegelin, Yvonne http://orcid.org/0000-0002-1315-4100
Kuhle, Jens
Schädelin, Sabine
Datta, Alexandre N.
Magon, Stefano
Amann, Michael
Barro, Christian
Ramelli, Gian Paolo
Heesom, Kate
Barde, Yves-Alain
Weber, Peter
Kappos, Ludwig
Funding for this research was provided by:
Novartis Pharma AG Switzerland
Article History
Received: 7 September 2020
Accepted: 20 December 2020
First Online: 6 January 2021
Ethics approval and consent to participate
: The study was approved by the local ethics committee (EKNZ, Ref. 197/12) and by the Swiss agency for therapeutic products Swissmedic (Ref. 2013DR1109). Written informed consent was obtained from all parents of participating children [RS (all) and HC (if children were younger than 14)] and from all healthy children (age 6–10 oral informed consent only, but written informed consent from parents).The study was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments.
: Not applicable.
: Yvonne Naegelin’s employer, the University Hospital Basel, received payments for lecturing from Celgene GmbH and Teva Pharma AG that were exclusively used for research support, not related to this study. Jens Kuhle received speaker fees, research support, travel support, and/or served on advisory boards by ECTRIMS, Swiss MS Society, Swiss National Research Foundation, (320030_189140/1), University of Basel, Bayer, Biogen, Celgene, Merck, Novartis, Roche, Sanofi. Alexandre N. Datta has served on scientific advisory boards for UCB, Eisai, and Nutricia. He has consultancy activities for Roche, Idorsia, Neurocrine, and Epilog. He has received funding for travel from UCB, Sanofi, Eisai, and Nutricia. Stefano Magon is an employee of F. Hoffmann-La Roche Ltd. Roche was not involved in the study. Ludwig Kappos’s institution (University Hospital Basel) received in the last 3 years and used exclusively for research support at the Department: steering committee, advisory board, consultancy fees and support of educational activities from: Actelion, Allergan, Almirall, Baxalta, Bayer, Biogen, Celgene/Receptos, CSL-Behring, Desitin, Excemed, Eisai,Genzyme, Japan Tobacco, Merck, Minoryx, Novartis, Pfizer, F. Hoffmann-La Roche Ltd, Sanofi Aventis, Santhera, Teva, and license fees for Neurostatus-UHB products; the Research of the MS Center in Basel has been supported by grants from Bayer, Biogen, Novartis, the Swiss MS Society, the Swiss National Research Foundation, Innosuisse, the European Union, and Roche Research Foundations. Sabine Schädelin, Michael Amann, Christian Barro, Gian Paolo Ramelli, Kate Heesom, Yves Alain Barde, and Peter Weber have nothing to disclose.