Funding for this research was provided by:
Alexion Pharmaceuticals (Genetic testing was supported by an unrestricted grant from Alexion Pharmaceuticals Inc, which had no role in the study design or data analysis.)
Received: 31 August 2019
Accepted: 24 January 2020
First Online: 17 February 2020
Ethics approval and consent to participate
: The study adhered to the tenets of the Declaration of Helsinki and approval was obtained from La Paz University Hospital’s ethics committee. Each subject provided written informed consent prior to inclusion.
: Not applicable
: P. Aguado has received fees for advisory board participation from Alexion (Spain) and is a recipient of an unrestricted research grant from this pharmaceutical company, but not for this manuscript. The rest of authors declare they do not have any other conflict of interest regarding the publication of this article.