Received: 8 March 2022
Accepted: 17 August 2022
First Online: 14 September 2022
: The Natural History Database is managed and maintained by the TSC Alliance, MD, USA, data were de-identified, and no ethics committee approval was sought. Statistical analysis was performed on the de-identified data. The views expressed in this article are those of the authors and do not necessarily reflect the opinion of the TSC Alliance.
: SB and EB are employees of Nobelpharma America, LLC. SR and JN are employees of TSC Alliance, a non-profit organization which reports revenue from individual donors and corporations including Aeovian, Jazz Pharmaceuticals, BridgeBio, LivaNova, Lundbeck, Mallinckrodt, MassMutual, Neurelis, Nobelpharma America, Novartis, Ovid, UCB, and Upsher-Smith.