Khalil, Bilal
Chhangani, Deepak
Wren, Melissa C.
Smith, Courtney L.
Lee, Jannifer H.
Li, Xingli
Puttinger, Christian
Tsai, Chih-Wei
Fortin, Gael
Morderer, Dmytro
Gao, Junli
Liu, Feilin
Lim, Chun Kim
Chen, Jingjiao
Chou, Ching-Chieh
Croft, Cara L.
Gleixner, Amanda M.
Donnelly, Christopher J.
Golde, Todd E.
Petrucelli, Leonard
Oskarsson, Björn
Dickson, Dennis W.
Zhang, Ke
Shorter, James
Yoshimura, Shige H.
Barmada, Sami J.
Rincon-Limas, Diego E.
Rossoll, Wilfried http://orcid.org/0000-0002-9622-541X
Funding for this research was provided by:
Robert Packard Center for ALS Research, Johns Hopkins University (Robert Packard Center for ALS Research, Johns Hopkins University, Robert Packard Center for ALS Research, Johns Hopkins University)
Mayo Clinic Center for Biomedical Discovery (Mayo Clinic Center for Biomedical Discovery)
BrightFocus Foundation (A2021038S)
NIH (R33NS110960, RF1AG068581, R01AG077771, P01NS084974, P30AG062677, R01NS097542, R01NS113943, R01NS117461, R35NS097273, U54NS123743, P01NS084974, R01AG059871, R21NS096647, R01NS105756, R21AG064940, R01NS127187, R01AG077771)
U.S. Department of Defense (W81XWH-19–1-0193)
Mayo Clinic Ventures (Mayo Clinic Ventures)
CureSMA (Audrey Lewis Young Investigator Award)
Rainwater Charitable Foundation (Rainwater Charitable Foundation)
Robert E. Jacoby Professorship (Robert E. Jacoby Professorship)
Center for Scientific Review (P30AG072931)
LiveLikeLou Center at the University of Pittsburgh Brain Institute (LiveLikeLou Center at the University of Pittsburgh Brain Institute)
Target ALS (Target ALS)
Article History
Received: 9 November 2022
Accepted: 23 November 2022
First Online: 8 December 2022
Declarations
:
: All donors had provided written informed consent for the use of autopsy material and of clinical and genetic information for research purposes. Brain and spinal cord tissue was obtained postmortem following IRB review. All animal procedures were conducted in accordance with the guidelines set forth by the Institutional Animal Care and Use Committee (IACUC) at Mayo Clinic, and study protocols were reviewed and approved prior to performing the experimental procedures described.
: All authors read and approved the final manuscript.
: The authors declare they have no financial competing interests. BK and WR are co-inventors on a patent relating to the content of the manuscript.