Funding for this research was provided by:
Biotechnology and Biological Sciences Research Council ([BB/L007576/1].)
Gerald Kerkut Charitable Trust (PhD Studentships)
Wessex Medical Research (Innovation Grant)
Alzheimer's Research UK Southcoast Network (Summer Studentship)
Institute for Life Sciences (PhD studentship)
Received: 4 June 2019
Accepted: 21 June 2019
First Online: 4 July 2019
Ethics approval and consent to participate
: Anonymised human brain tissue samples: All patients provided informed consent for participation. Ethical approval: REC Reference: 12/NW/0 794, HTA LN: 12009 under the Southampton Biorepository Research. Study reference number: SRB002/14 or the NOII study: REC reference: 11/SC/0204 Sponsor number: RHM NEU0169.Animal tissue: Animal care and experimental procedures were conducted in accordance with UK Home Office regulations under the Animals (Scientific Procedures) Act of 1986.
: Not applicable.
: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.