Mateos, Maria V.
Gavriatopoulou, Maria
Facon, Thierry
Auner, Holger W.
Leleu, Xavier
Hájek, Roman
Dimopoulos, Meletios A.
Delimpasi, Sosana
Simonova, Maryana
Špička, Ivan
Pour, Ludĕk
Kriachok, Iryna
Pylypenko, Halyna
Doronin, Vadim
Usenko, Ganna
Benjamin, Reuben
Dolai, Tuphan K.
Sinha, Dinesh K.
Venner, Christopher P.
Garg, Mamta
Stevens, Don A.
Quach, Hang
Jagannath, Sundar
Moreau, Philippe
Levy, Moshe
Badros, Ashraf Z.
Anderson, Larry D. Jr.
Bahlis, Nizar J.
Cavo, Michele
Chai, Yi
Jeha, Jacqueline
Arazy, Melina
Shah, Jatin
Shacham, Sharon
Kauffman, Michael G.
Richardson, Paul G.
Grosicki, Sebastian
Clinical trials referenced in this document:
Documents that mention this clinical trial
Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma
https://doi.org/10.1186/s13045-021-01071-9
Funding for this research was provided by:
Karyopharm Therapeutics
Article History
Received: 3 March 2021
Accepted: 29 March 2021
First Online: 13 April 2021
Declarations
:
: The study was approved and performed in accordance with the International Conference on Harmonization, the Guidelines for Good Clinical Practice, appropriate regulatory requirements, and with approval of institutional review boards at individual enrolling institutions. All patients provided written informed consent before study start.
: Not applicable.
: M-VM has served as member of advisory boards or received honoraria from Janssen, BMS-Celgene, Takeda, Amgen, Sanofi, Oncopeptides, GSK, Adaptive, Pfizer, Regeneron, Roche and Sea-Gen. MG reports (Maria Gavriatopoulou) receiving honoraria from Amgen, Karyopharm Therapeutics, Takeda, Genesis Pharma, and Janssen-Cilag. TF reports an advisory board role for Karyopharm, Amgen, Roche and Oncopeptides; an advisory board role and a speaker bureau role for Janssen, Celgene/BMS, and Takeda. HWA reports an advisory role for Takeda and Karyopharm; grant from Amgen; and a speaker’s bureau role for Janssen. NB reports grants and personal fees from Celgene; personal fees from Janssen, Amgen, Takeda, Abbvie, GSK and Karyopharm. RH has had a consultant or advisory relationship with Janssen, Amgen, Celgene, AbbVie, BMS, Novartis, PharmaMar, and Takeda; has received honoraria from Janssen, Amgen, Celgene, BMS, PharmaMar, and Takeda; has received research funding from Janssen, Amgen, Celgene, BMS, Novartis, and Takeda. IS reports personal fees from Janssen-Cilag, Takeda, Sanofi Aventis and Novartis; personal fees and non-financial support from Colgene, BMS and Amgen. IK reports a consulting role, an advisory role, and a speaker’s bureau role for Takeda, Janssen, Roche, Abbvie and MSD; Travel support by Takeda, MSD, Roche, Abbvie and Janssen. CPV has received honoraria from BMS/Celgene, Janssen, Sanofi, Amgen, GSK, and Takeda. MG (Mamta Garg) reports support for attending conferences from Takeda; an advisory role for Amgen, Takeda, Jansen, Novartis and Celgene; and a speaker’s bureau role for Janssen. HQ reports grants from and an advisory board role for Amgen, Celgene, Karyopharm, GlaxoSmithKline; non-financial support and research drug supply from Sanofi; an advisory board role for Janssen Cilag and Specialized therapeutics. SJ reports consulting services for AbbVie, Bristol-Myers Squibb, Janssen Pharmaceuticals, Merck & Co. PM reports personal fees from Celgene, Amgen, Takeda, Janssen and Abbvie. ML reports receiving consulting fees and lecture fees from Takeda, Celgene, Seattle Genetics, AbbVie, Jazz Pharmaceuticals, Gilead Sciences, Bristol-Myers Squibb, Amgen, Spectrum Pharmaceuticals, and Janssen. NJB reports grants and personal fees from Celgene; personal fees from Janssen, Amgen, Takeda, Abbvie, GSK and Karyopharm.YC, JJ, MA, JS and MGK are employees of and stockholders of Karyopharm. SS reports being employed by and owning stock in Karyopharm Therapeutics, holding patents (8999996, 9079865, 9714226, PCT/US12/048319, and I574957) on hydrazide-containing nuclear transport modulators and uses, and holding pending patents (PCT/US12/048319, 499/2012, PI20102724, and 2012000928) on hydrazide-containing nuclear transport modulators and uses. PGR reports receiving grant support and honoraria from Oncopeptides, Celgene, and Takeda, grant support from Bristol-Myers Squibb, and honoraria from Amgen, Janssen, and Karyopharm Therapeutics. All other authors declare no competing interests.