Funding for this research was provided by:
Japan Society for the Promotion of Science (JP15K06832, JP25253081, JP16H06276, 16K08661, AA005)
Japan Agency for Medical Research and Development (JP17ck0106017)
Ministry of Education, Culture, Sports, Science and Technology (221S0001)
Korea Research Institute of Bioscience and Biotechnology (KRIBB Research Initiative Program)
Received: 17 January 2019
Accepted: 28 February 2019
First Online: 12 March 2019
Ethics approval and consent to participate
: This study was approved by the Medical Research Ethics Committee for Genetic Research of Tokyo Medical and Dental University, and informed consent was obtained from all patients. This study was also approved by Institutional Review Boards for Human Subject Research at Seoul National University Hospital and Seoul National University Bundang Hospital, and informed consent was obtained from all patients in both institutes. This research was approved by the Institutional Animal Care and Use Committee of Tokyo Medical and Dental University, and animals used in the present study were maintained in accordance with the Guideline for Care and Use of Laboratory Animals of the Institutional Animal Care and Use Committees of Tokyo Medical and Dental University.
: Not applicable
: The authors declare that they have no competing interests.
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